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Antibody enzyme prodrug therapy—Caroline Springer andRichard Begent Tom Connors saw the potential of selective prodrug activation in the tumour at a very early stage in his career and was publishing on the subject in His interests included nitroreductase and microsomal activation of cyclophosphamide; however, targeting an enzyme to the tumour did not become feasible until the s when Ken Bagshawe's CRC laboratories at Charing Cross Hospital described antibody-directed enzyme prodrug therapy ADEPT Bagshawe, ; Bagshawe et al, The ADEPT approach separates the cytotoxic prodrug from the targeting antibody in a two-phase system that has benefits over a one phase chemoimmunoconjugate, immunotoxin or radioimmunoconjugate. The antibody binds to an antigen that is preferentially expressed on the surface or in the interstitial spaces of the tumour cells. The antibody—enzyme complex is administered and allowed to accumulate at the tumour site. Time is allowed for the clearance of the conjugate from blood and normal tissues.
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Roseanne spin-off The Conners announces Maya Lynne Robinson has joined cast as DJ's wife Geena

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Share this article Share 'Her character 2nd Lieutenant Geena Conner, whom a younger DJ was reluctant to kiss in his school play, comes full circle as his wife and Mary's mother, bringing back a little piece of Conner history. The on-screen couple shared an embrace as The Conners' Twitter account announced the big news The official Twitter account of The Conners also shared the big news. Of course, Roseanne Barr will not be appearing in the upcoming spin-off. Maya flashed a huge smile as she enjoyed a playful moment with her co-star She has repeatedly apologized for any offence that the tweet caused as well as to the cast and crew of Roseanne, but refuses to accept that it was racist.
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