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The most common intracranial anomaly is the presence of choroid plexus cysts , which are pockets of fluid on the brain. These are not problematic in themselves, but their presence may be a marker for trisomy The additional chromosome usually occurs before conception. The effects of the extra copy vary greatly, depending on the extent of the extra copy, genetic history, and chance. Edwards syndrome occurs in all human populations, but is more prevalent in female offspring.